The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesWB: 1/500 - 1/1000.
In Western blot, this antibody is expected to detect a band of approximately 39 kDa, which corresponds to the predicted molecular weight of KLK L1.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Tissue specificityExpressed in prostate.
Involvement in diseaseDefects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
Sequence similaritiesBelongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain.
References for Anti-Kallikrein 4 antibody (ab3636)
This product has been referenced in:
Stephenson SA et al. Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. J Biol Chem274:23210-4 (1999).
Read more (PubMed: 10438493) »