Anti-Kappa + CD19 antibody [GA160 + CB19] (Dual color: FITC + PE) (ab1241)

Overview

  • Product nameAnti-Kappa + CD19 antibody [GA160 + CB19] (Dual color: FITC + PE)
  • Description
    Mouse monoclonal [GA160 + CB19] to Kappa + CD19 (Dual color: FITC + PE)
  • ConjugationDual color: FITC + PE
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • General notes

    This product is a mixture of two clones: Kappa = Clone:L1C1, Isotype:IgG1, Label:FITC CD19 = Clone:CB19, Isotype:IgG1, Label:PE

    The Kappa antigen is present in serum on all immunoglobulins bearing kappa light chains. It is also present on approximately 50% of normal human B lymphocytes. CD19: This antigen (MW = 95kDa) is present on 10-15% of human peripheral blood lymphocytes and approximately 60% of splenic lymphocytes. It is not expressed on T lymphocytes, granulocytes, activated T cells or monocytes. Moreover, CD19 is present on principal acute and chronic B cell leukemias and lymphomas.

    Studies of clonality of B cell leukemias in human lysed whole peripheral blood or mononuclear cells separated by density gradient. Studies of clonality of B cell lymphomas in tissue. Kappa (FITC) / CD19 (PE) immunofluorescence analysis can be performed on a flow cytometer equipped with an excitation source of 488nm and fitted with logarithmic amplifiers. 10µl ofKappa (FITC) / CD19 (PE) is sufficient for labelling 1x10<6 cells.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C.
  • Storage bufferPBS with 0.5% BSA and 0.1% sodium azide
  • Concentration information loading...
  • Primary antibody notesThe Kappa antigen is present in serum on all immunoglobulins bearing kappa light chains. It is also present on approximately 50% of normal human B lymphocytes. CD19: This antigen (MW = 95kDa) is present on 10-15% of human peripheral blood lymphocytes and approximately 60% of splenic lymphocytes. It is not expressed on T lymphocytes, granulocytes, activated T cells or monocytes. Moreover, CD19 is present on principal acute and chronic B cell leukemias and lymphomas.
  • ClonalityMonoclonal
  • Clone numberGA160 + CB19
  • Myelomaunknown
  • Light chain typeunknown
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab1241 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

Target

  • RelevanceCD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It is expressed on approximately 10% of normal human peripheral blood cells and approximately 60% of splenic lymphocytes. It is not expressed on granulocytes, monocytes or T cells as defined by CD3 expression. Kappa is an antigen present in the serum of all immunoglobulins bearing kappa light chains. It is also present on 50-70% of normal human B-cells. cd19 antigen is a member of the immunoglobulin superfamily and has two Ig like domains. It is a critical signal transduction molecule that regulates B lymphocyte development, activation and differentiation. It is expressed on the majority of B-cell lineage malignancies, including most acute lymphoblastic leukaemias.
  • Cellular localizationCell Membrane and Cytoplasmic
  • Database links
  • Alternative names
    • B lymphocyte antigen CD19 antibody
    • CD19 molecule antibody
    • CD19 antigen antibody
    • Differentiation antigen CD19 antibody
    • Ig kappa chain V-I region HK101 antibody
    • IGKC antibody
    • Immunoglobulin kappa constant antibody
    • immunoglobulin kappa light chain antibody
    see all

References for Anti-Kappa + CD19 antibody [GA160 + CB19] (Dual color: FITC + PE) (ab1241)

ab1241 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"