Overview

  • Product nameAnti-KAT1 / HAT1 antibody
    See all KAT1 / HAT1 primary antibodies
  • Description
    Rabbit polyclonal to KAT1 / HAT1
  • Specificityab12163 specifically recognizes human HAT1.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Chicken, Human
  • Immunogen

    Synthetic peptide:

    EESFQELVEDYRRVIERLAQE

    with N-terminal added lysine conjugated to KLH, corresponding to amino acids 399-419 of Human HAT1. The corresponding sequence differs by three amino acids in chicken and by one amino acid in mouse (putative sequence).

  • Positive control
    • Whole extracts of human 293 cells, mouse NIH-3T3 cells, or chicken fibroblasts.
  • General notesStorage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab12163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2500. Detects a band of approximately 46 kDa.

Target

  • FunctionAcetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
  • Sequence similaritiesBelongs to the HAT1 family.
  • Developmental stageHighly expressed in mitotic cells (at protein level).
  • Cellular localizationNucleus matrix and Cytoplasm. Nucleus. Nucleus matrix. Nucleus > nucleoplasm. Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.
  • Information by UniProt
  • Database links
  • Alternative names
    • HAT 1 antibody
    • hat1 antibody
    • HAT1_HUMAN antibody
    • Histidine aminotransferase 1 antibody
    • Histone acetyltransferase 1 antibody
    • Histone acetyltransferase 1 antibody
    • Histone acetyltransferase type B catalytic subunit antibody
    • KAT1 antibody
    see all

References for Anti-KAT1 / HAT1 antibody (ab12163)

ab12163 has not yet been referenced specifically in any publications.

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