Anti-KAT13C / NCOA2 (phospho S736) antibody (ab78899)


  • Product nameAnti-KAT13C / NCOA2 (phospho S736) antibody
    See all KAT13C / NCOA2 primary antibodies
  • Description
    Rabbit polyclonal to KAT13C / NCOA2 (phospho S736)
  • Specificityab78899 detects endogenous levels of KAT13C / NCOA2 only when phosphorylated at serine 736.
  • Tested applicationsSuitable for: WB, IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthesized phosphopeptide derived from human KAT13C/ NCOA2 around the phosphorylation site of serine 736 (P-V-SP-P-K).

  • Positive control
    • Human breast carcinoma tissue; extracts from HeLa cells, treated with TSA (400 nM, 24 hours)



Our Abpromise guarantee covers the use of ab78899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 159 kDa.
IHC-P 1/50 - 1/100.
ELISA 1/5000.


  • FunctionTranscriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.
  • Involvement in diseaseNote=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
  • Sequence similaritiesBelongs to the SRC/p160 nuclear receptor coactivator family.
    Contains 1 bHLH (basic helix-loop-helix) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • DomainContains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
    The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.
    Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
  • Post-translational
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • bHLHe75 antibody
    • Class E basic helix-loop-helix protein 75 antibody
    • glucocorticoid receptor interacting protein 1 antibody
    • GRIP 1 antibody
    • GRIP1 antibody
    • hTIF2 antibody
    • MED1 antibody
    • MGC138808 antibody
    • NCoA 2 antibody
    • NCoA-2 antibody
    • Ncoa2 antibody
    • NCOA2_HUMAN antibody
    • Nuclear receptor coactivator 2 antibody
    • Oncogene FGR antibody
    • p160 antibody
    • SRC 2 antibody
    • src2 antibody
    • Steroid receptor coactivator 2 antibody
    • TIF 2 antibody
    • TIF2 antibody
    • Transcriptional intermediary factor 2 antibody
    see all

Anti-KAT13C / NCOA2 (phospho S736) antibody images

  • All lanes : Anti-KAT13C / NCOA2 (phospho S736) antibody (ab78899) at 1/500 dilution

    Lane 1 : extracts from HeLa cells, treated with TSA (400 nM, 24 hours) with no immunizing peptide
    Lane 2 : extracts from HeLa cells, treated with TSA (400 nM, 24 hours) with immunizing peptide at 10 µg

    Lysates/proteins at 10 µg per lane.

    Predicted band size : 159 kDa
    Observed band size : >170 kDa (why is the actual band size different from the predicted?)
  • Immunohistochemical analysis of KAT13C / NCOA2 in paraffin embedded human breast carcinoma tissue, using a 1/50 dilution of ab78899.
    Left: untreated sample.
    Right: sample treated with immunizing peptide.

References for Anti-KAT13C / NCOA2 (phospho S736) antibody (ab78899)

ab78899 has not yet been referenced specifically in any publications.

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