The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/50 - 1/100. Detects a band of approximately 85 kDa (predicted molecular weight: 94 kDa).
FunctionFunctions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Tissue specificityExpressed in all tissues tested, with most abundant expression in ovary.
Sequence similaritiesBelongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain.