Overview

  • Product nameAnti-KAT2B / PCAF antibody
    See all KAT2B / PCAF primary antibodies
  • Description
    Mouse monoclonal to KAT2B / PCAF
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: LEEEVYSQNS PIWDQDFLSA SSRTSQLGIQ TVINPPPVAG TISYNSTSSS LEQPNAGSSS PACKASSGLE ANPGEKRKMT DSHVLEEAKK PRVMGDIPME , corresponding to amino acids 353-452 of Human PCAF

Properties

Applications

Our Abpromise guarantee covers the use of ab56535 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionFunctions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
    • Tissue specificityUbiquitously expressed but most abundant in heart and skeletal muscle.
    • Sequence similaritiesBelongs to the GCN5 family.
      Contains 1 bromo domain.
      Contains 1 N-acetyltransferase domain.
    • DomainThe bromodomain mediates binding to HIV-1 Tat.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • CAF antibody
      • CREBBP associated factor antibody
      • GCN5 antibody
      • GCN5L antibody
      • GCN5L1 antibody
      • Histone acetylase PCAF antibody
      • Histone acetyltransferase KAT2B antibody
      • Histone acetyltransferase PCAF antibody
      • K(lysine) acetyltransferase 2B antibody
      • KAT2B antibody
      • KAT2B_HUMAN antibody
      • Lysine acetyltransferase 2B antibody
      • P antibody
      • P/CAF antibody
      • p300/CBP associated factor antibody
      • P300/CBP-associated factor antibody
      • Pcaf antibody
      see all

    Anti-KAT2B / PCAF antibody images

    • Western blot against tagged recombinant protein immunogen using ab56535 PCAF antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-KAT2B / PCAF antibody (ab56535)

    ab56535 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"