Anti-KAT3A / CBP antibody, prediluted (ab53901)


  • Product nameAnti-KAT3A / CBP antibody, prediluted
    See all KAT3A / CBP primary antibodies
  • Description
    Rabbit polyclonal to KAT3A / CBP, prediluted
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide:


    , corresponding to amino acids 2422-2441 of Human CBP

  • Positive control
    • Hela cells and tonsil tissue


Our Abpromise guarantee covers the use of ab53901 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: Ready-to-use, treat for 30 min at RT.
    Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAcetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
    • Involvement in diseaseNote=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with MYST3/MOZ; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with MYST4/MORF. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.
      Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
    • Sequence similaritiesContains 1 bromo domain.
      Contains 1 KIX domain.
      Contains 2 TAZ-type zinc fingers.
      Contains 1 ZZ-type zinc finger.
    • DomainThe KIX domain mediates binding to HIV-1 Tat.
    • Post-translational
      Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
      Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX.
    • Cellular localizationCytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • CBP antibody
      • CBP_HUMAN antibody
      • CREB binding protein antibody
      • CREB-binding protein antibody
      • Crebbp antibody
      • Cyclic AMP responsive enhancer binding protein antibody
      • KAT3A antibody
      • RSTS antibody
      • RTS antibody
      • Rubinstein Taybi syndrome antibody
      see all

    Anti-KAT3A / CBP antibody, prediluted images

    • Human tonsil tissue stained with neat ab53901

    References for Anti-KAT3A / CBP antibody, prediluted (ab53901)

    ab53901 has not yet been referenced specifically in any publications.

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