Overview

  • Product nameAnti-KAT6B / MORF antibody
    See all KAT6B / MORF primary antibodies
  • Description
    Rabbit polyclonal to KAT6B / MORF
  • SpecificityThis antibody reacts with MORF and MORF alpha.
  • Tested applicationsSuitable for: WB, IHC-P, IPmore details
  • Species reactivity
    Reacts with: Cow, Human
  • Immunogen

    Synthetic peptide corresponding to Cow KAT6B/ MORF (N terminal) conjugated to keyhole limpet haemocyanin.
    Database link: A7E390

Properties

Applications

Our Abpromise guarantee covers the use of ab58823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/7500. Detects a band of approximately 230 kDa (predicted molecular weight: 231 kDa).
IHC-P 1/1000.
IP Use at an assay dependent concentration.

Target

  • FunctionHistone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
  • Tissue specificityUbiquitously expressed, with high levels in heart, pancreas, testis and ovary.
  • Involvement in diseaseNote=A chromosomal aberration involving MYST4 may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP.
  • Sequence similaritiesBelongs to the MYST (SAS/MOZ) family.
    Contains 1 C2HC-type zinc finger.
    Contains 1 H15 (linker histone H1/H5 globular) domain.
    Contains 2 PHD-type zinc fingers.
  • DomainThe N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
  • Post-translational
    modifications
    Autoacetylated.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp313G1618 antibody
    • FLJ90335 antibody
    • Histone acetyltransferase MORF antibody
    • Histone acetyltransferase MOZ2 antibody
    • Histone acetyltransferase MYST4 antibody
    • KAT 6B antibody
    • KIAA0383 antibody
    • Monocytic leukemia zinc finger protein related factor antibody
    • Monocytic leukemia zinc finger protein-related factor antibody
    • MOZ 2 antibody
    • MOZ antibody
    • MOZ related factor antibody
    • MOZ YBF2/SAS3 SAS2 and TIP60 protein 4 antibody
    • MOZ2 antibody
    • MYST 4 antibody
    • MYST histone acetyltransferase (monocytic leukemia) 4 antibody
    • MYST protein 4 antibody
    • MYST-4 antibody
    • MYST4 antibody
    • MYST4_HUMAN antibody
    • OTTHUMP00000019866 antibody
    • OTTHUMP00000019867 antibody
    • OTTHUMP00000019869 antibody
    • OTTHUMP00000019870 antibody
    • QKF antibody
    • Querkopf antibody
    • SAS2 and TIP60 protein 4 antibody
    • YBF2/SAS3 antibody
    see all

References for Anti-KAT6B / MORF antibody (ab58823)

This product has been referenced in:
  • Simpson MA  et al. De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome. Am J Hum Genet 90:290-4 (2012). WB . Read more (PubMed: 22265017) »
  • Kraft M  et al. Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice. J Clin Invest 121:3479-91 (2011). WB ; Human . Read more (PubMed: 21804188) »

See all 2 Publications for this product

Product Wall

The peptide used to produce this antibody is 90% conserved in a mouse, therefore the antibody is likely to react with mouse.

Thank you for your interest in these products. The secondary antibody used in the study was not from abcam but we do have several similar products in stock. ab6721 is a goat polyclonal to rabbit IgG and has been used extensively in Western blotting whi...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"