Overview

  • Product nameAnti-KATNA1 antibody
    See all KATNA1 primary antibodies
  • Description
    Rabbit polyclonal to KATNA1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 347-396 (DDPSKMVMVL AATNFPWDID ALRRRLEKRI IPLPSAKGRE LLRISLR) of Mouse KATNA1.

  • Positive control
    • Mouse Spleen lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab113972 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 56 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionSevers microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays, such as during disassembly of interphase microtubules at the G2-M transition. May also be required for microtubule release from the centrosome after nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux. In neurons, microtubule release within the cell body may allow their subsequent transport into neuronal processes by microtubule dependent motor proteins. This transport is required for axonal growth.
  • Sequence similaritiesBelongs to the AAA ATPase family.
  • DomainThe N-terminus is sufficient for interaction with microtubules, although high affinity binding requires an intact C-terminal domain and ATP, which promotes oligomerization.
  • Cellular localizationCytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle pole. Predominantly cytoplasmic. Also localized to the interphase centrosome. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.
  • Information by UniProt
  • Database links
  • Alternative names
    • Katanin p60 ATPase containing subunit A1 antibody
    • Katanin p60 ATPase-containing subunit A1 antibody
    • Katanin p60 subunit A1 antibody
    • KATNA1 antibody
    • KTNA1_HUMAN antibody
    • OTTHUMP00000017392 antibody
    • OTTHUMP00000042860 antibody
    • p60 katanin antibody
    see all

Anti-KATNA1 antibody images

  • Anti-KATNA1 antibody (ab113972) at 1 µg/ml + Mouse spleen lysate at 10 µg

    Predicted band size : 56 kDa

References for Anti-KATNA1 antibody (ab113972)

ab113972 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"