Overview

  • Product nameKB-R7943
  • Description
    NCX inhibitor. TRPC blocker.
  • Biological descriptionPotent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = ~0.32 μM in guinea pig ventricular cells). Also potent blocker of TRPC channels (IC50 values are 0.46, 0.71 and 1.38 μM at TRPC3, TRPC6 and TRPC5, respectively).
  • Purity> 99%

Properties

    References for KB-R7943 (ab120284)

    This product has been referenced in:
    • Kraft R The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. Biochem Biophys Res Commun 361:230-6 (2007). Read more (PubMed: 17658472) »
    • Elias CL  et al. Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences. Am J Physiol Heart Circ Physiol 281:H1334-45 (2001). Read more (PubMed: 11514305) »
    • Iwamoto T  et al. A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1. J Biol Chem 271:22391-7 (1996). Read more (PubMed: 8798401) »
    • Watano T  et al. A novel antagonist, No. 7943, of the Na+/Ca2+ exchange current in guinea-pig cardiac ventricular cells. Br J Pharmacol 119:555-63 (1996). Read more (PubMed: 8894178) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"