Overview

  • Product name
    KB-R7943
  • Description
    NCX inhibitor. TRPC blocker.
  • Biological description
    Potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = ~0.32 μM in guinea pig ventricular cells). Also potent blocker of TRPC channels (IC50 values are 0.46, 0.71 and 1.38 μM at TRPC3, TRPC6 and TRPC5, respectively).
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Kraft R The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. Biochem Biophys Res Commun 361:230-6 (2007). Read more (PubMed: 17658472) »
  • Elias CL  et al. Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences. Am J Physiol Heart Circ Physiol 281:H1334-45 (2001). Read more (PubMed: 11514305) »
  • Iwamoto T  et al. A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1. J Biol Chem 271:22391-7 (1996). Read more (PubMed: 8798401) »
  • Watano T  et al. A novel antagonist, No. 7943, of the Na+/Ca2+ exchange current in guinea-pig cardiac ventricular cells. Br J Pharmacol 119:555-63 (1996). Read more (PubMed: 8894178) »

See 1 Publication for this product

Customer reviews and Q&As

KB-R7943 has been used to inhibit the reverse mode of Na+/Ca2+ exchanger (NCX) in mouse cerebellar slice cultures. The cerebellar slices of P8 mouse pups were treated with KB-R7943 (15 uM diluted in 1:1 DMSO/ETOH solution) for 7-9 days with 5% Co2 at 37 degree C . Further, these slices were fixed with cold 4% Paraformaldehyde and immunohistochemistry was performed on these slices using anti-Calbindin antibody (Swant).
The blockade of the reverse mode of NCX by KB-R7943 severely reduced the dendritic arbour of Purkinje cells and induced thickened distal dendrites in mouse cerebellar slice cultures.

Image description: Reduced dendritic arbour of mouse Purkinje cell with thickened distal dendrites.
Username

Mr. Pradeep Sherkhane

Verified customer

Submitted Aug 25 2017

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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