Overview

  • Product nameAnti-KChIP2 antibody
    See all KChIP2 primary antibodies
  • Description
    Mouse polyclonal to KChIP2
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Full length Human KChIP2 (NP_775283.1)

  • Positive control
    • Rat brain lysate with KChIP2 expression, KChIP2 transfected 293T cell lysate and HeLa cell.

Properties

Applications

Our Abpromise guarantee covers the use of ab88542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 31 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • FunctionRegulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart.
  • Tissue specificityExpressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.
  • Sequence similaritiesBelongs to the recoverin family.
    Contains 4 EF-hand domains.
  • Post-translational
    modifications
    Palmitoylated. Palmitoylation enhances association with the plasma membrane.
  • Cellular localizationCell membrane and Cell membrane. Detected on lipid rafts (By similarity).
  • Information by UniProt
  • Database links
  • FormThere are 9 isoforms produced by alternative splicing.
  • Alternative names
    • A type potassium channel modulatory protein 2 antibody
    • A-type potassium channel modulatory protein 2 antibody
    • Cardiac voltage gated potassium channel modulatory subunit antibody
    • Cardiac voltage-gated potassium channel modulatory subunit antibody
    • DKFZp566L1246 antibody
    • KChIP 2 antibody
    • KChIP2 antibody
    • KCIP2_HUMAN antibody
    • KCNIP 2 antibody
    • Kcnip2 antibody
    • Kv channel interacting protein 2 antibody
    • Kv channel-interacting protein 2 antibody
    • MGC17241 antibody
    • Potassium channel interacting protein 2 antibody
    • Potassium channel-interacting protein 2 antibody
    see all

Anti-KChIP2 antibody images

  • Anti-KChIP2 antibody (ab88542) at 1 µg/ml + Rat brain lysate with KChIP2 expression at 50 µg

    Predicted band size : 31 kDa
    Observed band size : 31 kDa
  • All lanes : Anti-KChIP2 antibody (ab88542) at 1 µg/ml

    Lane 1 : KChIP2 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 50 µg per lane.


    Predicted band size : 31 kDa
    Observed band size : 31 kDa
  • Immunofluorescence of ab88542 on HeLa cell with antibody concentration 10 ug/ml

References for Anti-KChIP2 antibody (ab88542)

ab88542 has not yet been referenced specifically in any publications.

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