Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab4991 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human KChIP 2, catalog ab3473. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • A type potassium channel modulatory protein 2
    • A-type potassium channel modulatory protein 2
    • Cardiac voltage gated potassium channel modulatory subunit
    • Cardiac voltage-gated potassium channel modulatory subunit
    • DKFZp566L1246
    • KChIP 2
    • KChIP2
    • KCIP2_HUMAN
    • KCNIP 2
    • Kcnip2
    • Kv channel interacting protein 2
    • Kv channel-interacting protein 2
    • MGC17241
    • Potassium channel interacting protein 2
    • Potassium channel-interacting protein 2
    see all
  • Function
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart.
  • Tissue specificity
    Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.
  • Sequence similarities
    Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • Post-translational
    modifications
    Palmitoylated. Palmitoylation enhances association with the plasma membrane.
  • Cellular localization
    Cell membrane and Cell membrane. Detected on lipid rafts (By similarity).
  • Information by UniProt

References

ab4991 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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