Overview

  • Product name
    Anti-KCNC1 antibody [N16B/8]
    See all KCNC1 primary antibodies
  • Description
    Mouse monoclonal [N16B/8] to KCNC1
  • Host species
    Mouse
  • Specificity
    Weak cross reactivity with human.
  • Tested applications
    Suitable for: IHC-Fr, IHC-P, WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Fusion protein, corresponding to cytoplasmic C terminal amino acids 437-585 of Rat KCNC1 (NP_036988).

  • Positive control
    • Rat brain lysate.
  • General notes

    The clone number has been updated from S16B-8 to N16B/8, both clone numbers name the same antibody clone.

     

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: 50% Glycerol, PBS, pH 7.4
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Monoclonal
  • Clone number
    N16B/8
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab84823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use a concentration of 0.1 - 1 µg/ml.
IHC-P Use a concentration of 0.1 - 1 µg/ml.
WB Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 58 kDa.
ICC/IF Use a concentration of 1 - 10 µg/ml.

Target

  • Function
    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
  • Involvement in disease
    Epilepsy, progressive myoclonic 7
  • Sequence similarities
    Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
  • Domain
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C230009H10Rik antibody
    • FLJ41162 antibody
    • FLJ42249 antibody
    • FLJ43491 antibody
    • Kcnc1 antibody
    • KCNC1_HUMAN antibody
    • Kcr2 1 antibody
    • KShIIIB antibody
    • Kv3.1 antibody
    • Kv4 antibody
    • MGC129855 antibody
    • NGK2 antibody
    • Potassium voltage-gated channel subfamily C member 1 antibody
    • Shaw antibody
    • Voltage gated potassium channel antibody
    • Voltage gated potassium channel subunit Kv3.1 antibody
    • Voltage-gated potassium channel subunit Kv3.1 antibody
    • Voltage-gated potassium channel subunit Kv4 antibody
    see all

Images

  • All lanes : Anti-KCNC1 antibody [N16B/8] (ab84823) at 1 µg/ml

    Lane 1 : Molecular weight marker
    Lane 2 : Tissue lysates prepared from rat brain

    Predicted band size: 58 kDa

References

This product has been referenced in:
  • Uchino K  et al. Therapeutic Effects of MicroRNA-582-5p and -3p on the Inhibition of Bladder Cancer Progression. Mol Ther 21:610-9 (2013). Read more (PubMed: 23295946) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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