• Product nameAnti-KCNC3 antibody
    See all KCNC3 primary antibodies
  • Description
    Rabbit polyclonal to KCNC3
  • Tested applicationsSuitable for: WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from N terminal domain of (human) KCNC3.



Our Abpromise guarantee covers the use of ab66637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000. Predicted molecular weight: 81 kDa.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.


  • FunctionThis protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
  • Involvement in diseaseDefects in KCNC3 are the cause of spinocerebellar ataxia type 13 (SCA13) [MIM:605259]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients.
  • Sequence similaritiesBelongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily.
  • DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Kcnc3 antibody
    • KCNC3_HUMAN antibody
    • KSHIIID antibody
    • KV3.3 antibody
    • Potassium voltage gated channel Shaw related subfamily member 3 antibody
    • Potassium voltage gated channel subfamily C member 3 antibody
    • Potassium voltage-gated channel subfamily C member 3 antibody
    • SCA13 antibody
    • Shaw related subfamily, member 3 antibody
    • Shaw related voltage gated potassium channel protein 3 antibody
    • Spinocerebellar ataxia 13 antibody
    • Voltage gated potassium channel protein KV3.3 antibody
    • Voltage gated potassium channel subunit Kv3.3 antibody
    • Voltage-gated potassium channel subunit Kv3.3 antibody
    see all

References for Anti-KCNC3 antibody (ab66637)

ab66637 has not yet been referenced specifically in any publications.

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