Overview

  • Product nameAnti-KCNC3 antibody
    See all KCNC3 primary antibodies
  • Description
    Rabbit polyclonal to KCNC3
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Guinea pig, Cow, Cat
  • Immunogen

    Synthetic peptide corresponding to a region within the internal sequence amino acids 468-517 (YAERIGADPD DILGSNHTYF KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM) of human KCNC3 (NP_004968).

  • Positive control
    • 293T cell lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesPurified by peptide affinity chromatography method.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab83556 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay, 1/62500.

WB Use a concentration of 1 µg/ml. Predicted molecular weight: 81 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionThis protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
  • Involvement in diseaseDefects in KCNC3 are the cause of spinocerebellar ataxia type 13 (SCA13) [MIM:605259]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients.
  • Sequence similaritiesBelongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily.
  • DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Kcnc3 antibody
    • KCNC3_HUMAN antibody
    • KSHIIID antibody
    • KV3.3 antibody
    • Potassium voltage gated channel Shaw related subfamily member 3 antibody
    • Potassium voltage gated channel subfamily C member 3 antibody
    • Potassium voltage-gated channel subfamily C member 3 antibody
    • SCA13 antibody
    • Shaw related subfamily, member 3 antibody
    • Shaw related voltage gated potassium channel protein 3 antibody
    • Spinocerebellar ataxia 13 antibody
    • Voltage gated potassium channel protein KV3.3 antibody
    • Voltage gated potassium channel subunit Kv3.3 antibody
    • Voltage-gated potassium channel subunit Kv3.3 antibody
    see all

Anti-KCNC3 antibody images



  • Predicted band size : 81 kDa
    Western blot analysis of Human fetal lung tissue lysate labeling KCNC3 with ab83556 at 1.0µg/ml.
  • Anti-KCNC3 antibody (ab83556) at 1 µg/ml + 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 81 kDa
    Observed band size : 81 kDa
    Gel concentration 12%

References for Anti-KCNC3 antibody (ab83556)

ab83556 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"