Overview

  • Product name
  • Description
    Rabbit polyclonal to KCNIP4
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow, Dog
  • Immunogen

    Synthetic peptide, corresponding to amino acids 27-76 of Human KCNIP4.

Properties

Applications

Our Abpromise guarantee covers the use of ab28641 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 29 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use at an assay dependent concentration.

Target

  • Function
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents.
  • Tissue specificity
    Predominantly expressed in brain.
  • Sequence similarities
    Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • Domain
    The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • A type potassium channel modulatory protein 4 antibody
    • A-type potassium channel modulatory protein 4 antibody
    • CALP antibody
    • Calsenilin like protein antibody
    • Calsenilin-like protein antibody
    • HGNC:30083 antibody
    • KCHIP 4 antibody
    • KChIP4 antibody
    • KCIP4_HUMAN antibody
    • KCNIP 4 antibody
    • Kcnip4 antibody
    • Kv channel interacting protein 4 antibody
    • Kv channel-interacting protein 4 antibody
    • MGC44947 antibody
    • Potassium channel interacting protein 4 antibody
    • Potassium channel-interacting protein 4 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human brain tissue labelling KCNIP4 with ab28641 at 4-8µg/ml.

  • Anti-KCNIP4 antibody (ab28641) at 1 µg/ml + HepG2 cell lysate

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Observed band size : 29 kDa (why is the actual band size different from the predicted?)

References

ab28641 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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