Overview

  • Product nameAnti-KCNMB4 antibody
    See all KCNMB4 primary antibodies
  • Description
    Rabbit polyclonal to KCNMB4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Guinea pig, Cow, Cat, Pig
  • Immunogen

    Synthetic peptide designed within residues: CGADCRGTSQ YPCVQVYVNN SESNSRALLH SDEHQLLTNP KCSYIPPCKR, corresponding to internal sequence amino acids 72-121 of Human KCNMB4 (NP_055320)

  • Positive control
    • THP1 cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab89703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 24 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionRegulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
  • Tissue specificityPredominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.
  • Sequence similaritiesBelongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily.
  • DomainResistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics.
    N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • BK channel subunit beta 4 antibody
    • BK channel subunit beta-4 antibody
    • BKbeta4 antibody
    • Calcium activated potassium channel beta 4 subunit antibody
    • Calcium activated potassium channel subfamily M subunit beta 4 antibody
    • Calcium activated potassium channel subunit beta 4 antibody
    • Calcium-activated potassium channel antibody
    • Calcium-activated potassium channel subunit beta-4 antibody
    • Charybdotoxin receptor subunit beta 4 antibody
    • Charybdotoxin receptor subunit beta-4 antibody
    • Hbeta4 antibody
    • K(VCA)beta 4 antibody
    • K(VCA)beta-4 antibody
    • KCMB4_HUMAN antibody
    • KCNMB 4 antibody
    • Kcnmb4 antibody
    • Large conductance calcium dependent potassium ion channel beta 4 subunit antibody
    • Maxi K channel subunit beta 4 antibody
    • Maxi K channel subunit beta-4 antibody
    • Potassium large conductance calcium activated channel subfamily M beta member 4 antibody
    • Slo beta 4 antibody
    • Slo-beta-4 antibody
    • subfamily M subunit beta-4 antibody
    see all

Anti-KCNMB4 antibody images

  • Anti-KCNMB4 antibody (ab89703) at 1 µg/ml + THP1 cell lysate at 10 µg

    Secondary
    HRP-conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 24 kDa

References for Anti-KCNMB4 antibody (ab89703)

This product has been referenced in:
  • Yang J  et al. Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma. J Hematol Oncol 7:76 (2014). WB, IHC ; Human . Read more (PubMed: 25300797) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab89703.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"