Overview

  • Product name
  • Description
    Rabbit polyclonal to KCNQ3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Human
  • Immunogen

    Synthetic peptide: TPKHKKSQKG SAFTYPSQQS PRNEPYVARA ATSETEDQSM MGKFVKVERQ, corresponding to internal sequence amino acids 580-629 of Human KCNQ3

  • Positive control
    • Mouse heart lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Constituents: 98% PBS, 2% Sucrose
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab113948 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 97 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
  • Tissue specificity
    Predominantly expressed in brain.
  • Involvement in disease
    Defects in KCNQ3 are the cause of benign neonatal epilepsy type 2 (EBN2) [MIM:121201]. Benign neonatal epilepsy is characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset.
  • Sequence similarities
    Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.
  • Domain
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • BFNC 2 antibody
    • BFNC antibody
    • BFNC2 antibody
    • EBN 2 antibody
    • EBN2 antibody
    • KCNQ 3 antibody
    • KCNQ3 antibody
    • KCNQ3_HUMAN antibody
    • KQT like 3 antibody
    • KQT-like 3 antibody
    • KV7.3 antibody
    • Potassium channel subunit alpha KvLQT3 antibody
    • Potassium channel voltage gated subfamily Q member 3 antibody
    • Potassium voltage gated channel KQT like protein 3 antibody
    • Potassium voltage gated channel KQT like subfamily member 3 antibody
    • Potassium voltage gated channel subfamily KQT member 3 antibody
    • Potassium voltage-gated channel subfamily KQT member 3 antibody
    • Voltage gated potassium channel subunit Kv7.3 antibody
    • Voltage-gated potassium channel subunit Kv7.3 antibody
    see all

Anti-KCNQ3 antibody images



  • Predicted band size : 97 kDa
    Western blot analysis of CHO cell lysate (100µg) labeling KCNQ3 with ab113948 with 1:1000. AHRP-conjugated Goat anti-rabbit IgG (1:25000) was used as the secondary antibody.
  • Anti-KCNQ3 antibody (ab113948) at 1 µg/ml + Mouse heart lysate at 10 µg

    Predicted band size : 97 kDa
    Gel concentration: 6-18%

References for Anti-KCNQ3 antibody (ab113948)

ab113948 has not yet been referenced specifically in any publications.

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