• Product nameAnti-KCNQ3 antibody
    See all KCNQ3 primary antibodies
  • Description
    Rabbit polyclonal to KCNQ3
  • Tested applicationsSuitable for: IHC-P, IHC-Fr, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C terminal domain of human KCNQ3.



Our Abpromise guarantee covers the use of ab66640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
IHC-Fr Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 97 kDa.


  • FunctionProbably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
  • Tissue specificityPredominantly expressed in brain.
  • Involvement in diseaseDefects in KCNQ3 are the cause of benign neonatal epilepsy type 2 (EBN2) [MIM:121201]. Benign neonatal epilepsy is characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset.
  • Sequence similaritiesBelongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.
  • DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • BFNC 2 antibody
    • BFNC antibody
    • BFNC2 antibody
    • EBN 2 antibody
    • EBN2 antibody
    • KCNQ 3 antibody
    • KCNQ3 antibody
    • KCNQ3_HUMAN antibody
    • KQT like 3 antibody
    • KQT-like 3 antibody
    • KV7.3 antibody
    • Potassium channel subunit alpha KvLQT3 antibody
    • Potassium channel voltage gated subfamily Q member 3 antibody
    • Potassium voltage gated channel KQT like protein 3 antibody
    • Potassium voltage gated channel KQT like subfamily member 3 antibody
    • Potassium voltage gated channel subfamily KQT member 3 antibody
    • Potassium voltage-gated channel subfamily KQT member 3 antibody
    • Voltage gated potassium channel subunit Kv7.3 antibody
    • Voltage-gated potassium channel subunit Kv7.3 antibody
    see all

Anti-KCNQ3 antibody images

  • IHC image of ab66640 staining in human colon formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab66640, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

    For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

References for Anti-KCNQ3 antibody (ab66640)

ab66640 has not yet been referenced specifically in any publications.

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