Anti-KCNQ3 (phospho T246) antibody (ab62456)

Overview

  • Product name
    Anti-KCNQ3 (phospho T246) antibody
    See all KCNQ3 primary antibodies
  • Description
    Rabbit polyclonal to KCNQ3 (phospho T246)
  • Specificity
    ab62456 detects endogenous levels of KCNQ3 only when phosphorylated at threonine 246.
  • Tested applications
    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from human KCNQ3 around the phosphorylation site of threonine 246 (G-G-TP-W-K).

  • Positive control
    • Human brain tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab62456 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non phosphopeptide was removed by chromatography using non phosphopeptide corresponding to the phosphorylation site.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab62456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/20000.
IHC-P 1/50 - 1/100.

Target

  • Function
    Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
  • Tissue specificity
    Predominantly expressed in brain.
  • Involvement in disease
    Defects in KCNQ3 are the cause of benign neonatal epilepsy type 2 (EBN2) [MIM:121201]. Benign neonatal epilepsy is characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset.
  • Sequence similarities
    Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.
  • Domain
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • BFNC 2 antibody
    • BFNC antibody
    • BFNC2 antibody
    • EBN 2 antibody
    • EBN2 antibody
    • KCNQ 3 antibody
    • KCNQ3 antibody
    • KCNQ3_HUMAN antibody
    • KQT like 3 antibody
    • KQT-like 3 antibody
    • KV7.3 antibody
    • Potassium channel subunit alpha KvLQT3 antibody
    • Potassium channel voltage gated subfamily Q member 3 antibody
    • Potassium voltage gated channel KQT like protein 3 antibody
    • Potassium voltage gated channel KQT like subfamily member 3 antibody
    • Potassium voltage gated channel subfamily KQT member 3 antibody
    • Potassium voltage-gated channel subfamily KQT member 3 antibody
    • Voltage gated potassium channel subunit Kv7.3 antibody
    • Voltage-gated potassium channel subunit Kv7.3 antibody
    see all

Anti-KCNQ3 (phospho T246) antibody images

  • ab62456, at 1/50 dilution, staining KCNQ3 in paraffin embedded human brain tissue by Immunohistochemistry in the absence or presence of the immunising peptide.

References for Anti-KCNQ3 (phospho T246) antibody (ab62456)

ab62456 has not yet been referenced specifically in any publications.

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