Overview

  • Product nameAnti-KCNQ4 antibody
    See all KCNQ4 primary antibodies
  • Description
    Rabbit polyclonal to KCNQ4
  • SpecificityThis antibody reacts specifically with KCNQ4 protein.
  • Tested applicationsSuitable for: ICC/IF, IHC-Fr, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide derived from the N terminal domain of KCNQ4 protein

Properties

Applications

Our Abpromise guarantee covers the use of ab65797 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration. PubMed: 23242999
IHC-Fr Use at an assay dependent concentration. PubMed: 21740972
WB 1/500 - 1/5000. Predicted molecular weight: 77 kDa.

Target

  • FunctionProbably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors.
  • Tissue specificityExpressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
  • Involvement in diseaseDefects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A) [MIM:600101]. DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • Sequence similaritiesBelongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily.
  • DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The A-domain tail carries the major determinants of channel assembly specificity. Its coiled-coil region is Four-stranded.
  • Cellular localizationBasal cell membrane. Situated at the basal membrane of cochlear outer hair cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • DFNA 2 antibody
    • DFNA2 antibody
    • KCNQ 4 antibody
    • Kcnq4 antibody
    • KCNQ4_HUMAN antibody
    • KQT like 4 antibody
    • KQT-like 4 antibody
    • KV7.4 antibody
    • Potassium channel KQT like 4 antibody
    • Potassium channel subunit alpha KvLQT4 antibody
    • Potassium voltage gated channel KQT like protein 4 antibody
    • Potassium voltage gated channel KQT like subfamily member 4 antibody
    • Potassium voltage gated channel subfamily KQT member 4 antibody
    • Potassium voltage-gated channel subfamily KQT member 4 antibody
    • Voltage gated potassium channel subunit Kv7.4 antibody
    • Voltage-gated potassium channel subunit Kv7.4 antibody
    see all

References for Anti-KCNQ4 antibody (ab65797)

This product has been referenced in:
  • Iannotti FA  et al. Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels. Mol Biol Cell 24:274-84 (2013). ICC/IF ; Mouse . Read more (PubMed: 23242999) »
  • Ipavec V  et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res 64:397-409 (2011). IHC-Fr ; Rat . Read more (PubMed: 21740972) »

See all 3 Publications for this product

Product Wall

Is the Kv7.1 antibody also a rabbit polyclonal or was this raised in a different host species? Generally issues like this arise from an antibody (usually the secondary but sometimes the primary) reacting to the proteins within the blocking reagent. Hav...

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