Overview

  • Product nameAnti-KCNQ5 antibody
    See all KCNQ5 primary antibodies
  • Description
    Rabbit polyclonal to KCNQ5
  • Specificityab19319 detects the KCNQ5 from rat samples. This antibody is specific for KCNQ5 and does not detect KCNQ1, KCNQ2, KCNQ3 or KCNQ4.
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Synthetic peptide:

    CKAGESTDALSLPHVKLK

    , corresponding to amino acids 880-897 of Rat KCNQ5.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.05% Sodium Azide
    Constituents: PBS, 1mg/ml BSA
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab19319 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB 1/250. Detects a band of approximately 116 kDa.

Target

  • FunctionProbably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.
  • Tissue specificityStrongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.
  • Sequence similaritiesBelongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily.
  • DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • KCNQ 5 antibody
    • KCNQ5 antibody
    • KCNQ5_HUMAN antibody
    • KQT like 5 antibody
    • KQT-like 5 antibody
    • Kv7.5 antibody
    • OTTHUMP00000064152 antibody
    • OTTHUMP00000064153 antibody
    • Potassium channel alpha subunit KvLQT5 antibody
    • Potassium channel protein antibody
    • Potassium channel subunit alpha KvLQT5 antibody
    • Potassium voltage gated channel KQT like subfamily member 5 antibody
    • Potassium voltage gated channel subfamily KQT member 5 antibody
    • Potassium voltage-gated channel subfamily KQT member 5 antibody
    • Voltage gated potassium channel subunit Kv7.5 antibody
    • Voltage-gated potassium channel subunit Kv7.5 antibody
    see all

References for Anti-KCNQ5 antibody (ab19319)

ab19319 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"