Anti-KCNQ5 antibody - Carboxyterminal end (ab66740)

Overview

  • Product name
    Anti-KCNQ5 antibody - Carboxyterminal end
    See all KCNQ5 primary antibodies
  • Description
    Rabbit polyclonal to KCNQ5 - Carboxyterminal end
  • Tested applications
    Suitable for: WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C terminal domain of KCNQ5 (Human)

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: Whole serum
  • Purity
    Whole antiserum
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab66740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000. Predicted molecular weight: 99 kDa.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

Target

  • Function
    Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.
  • Tissue specificity
    Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.
  • Sequence similarities
    Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily.
  • Domain
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • KCNQ 5 antibody
    • KCNQ5 antibody
    • KCNQ5_HUMAN antibody
    • KQT like 5 antibody
    • KQT-like 5 antibody
    • Kv7.5 antibody
    • OTTHUMP00000064152 antibody
    • OTTHUMP00000064153 antibody
    • Potassium channel alpha subunit KvLQT5 antibody
    • Potassium channel protein antibody
    • Potassium channel subunit alpha KvLQT5 antibody
    • Potassium voltage gated channel KQT like subfamily member 5 antibody
    • Potassium voltage gated channel subfamily KQT member 5 antibody
    • Potassium voltage-gated channel subfamily KQT member 5 antibody
    • Voltage gated potassium channel subunit Kv7.5 antibody
    • Voltage-gated potassium channel subunit Kv7.5 antibody
    see all

References

ab66740 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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