Overview

  • Product nameAnti-KCNT1 antibody
    See all KCNT1 primary antibodies
  • Description
    Rabbit polyclonal to KCNT1
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C terminal region of Human KCNT1.

  • Positive control
    • Human brain tissue.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage bufferpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49.1% PBS, 50% Glycerol, 0.88% Sodium chloride
    Note: without Mg2+ and Ca2+
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab111051 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab111051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionOutwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro).
  • Tissue specificityHighest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.
  • Sequence similaritiesBelongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily.
    Contains 1 RCK N-terminal domain.
  • Post-translational
    modifications
    Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA100C15.2 antibody
    • EIEE14 antibody
    • ENFL5 antibody
    • KCa4.1 antibody
    • KCNT1 antibody
    • KCNT1_HUMAN antibody
    • Potassium channel subfamily T member 1 antibody
    • Potassium channel, sodium activated subfamily T, member 1 antibody
    • Potassium channel, subfamily T, member 1 antibody
    • Sequence like a calcium-activated K+ channel antibody
    • SLACK antibody
    • Slo2.2 antibody
    see all

Anti-KCNT1 antibody images

  • ab111051 1/50 dilution staining KCNT1 in paraffin-embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

References for Anti-KCNT1 antibody (ab111051)

ab111051 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"