Overview

  • Product nameAnti-KCTD11 antibody
    See all KCTD11 primary antibodies
  • Description
    Goat polyclonal to KCTD11
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide:

    PEVEYGRLGLQP

    by a Cysteine residue linker, corresponding to internal sequence amino acids 167-178 of Human KCTD11 (NP_001002914.1).

  • Positive control
    • HEK293 lysate overexpressing Human KCTD11.

Properties

Applications

Our Abpromise guarantee covers the use of ab113423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 26 kDa). Primary incubation time: 1 hour.

Target

  • RelevanceThe KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling. Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state.
  • Database links
  • Alternative names
    • C 17 orf 36 antibody
    • C17orf36 antibody
    • MGC 129844 antibody
    • Potassium channel tetramerisation domain containing 11 antibody
    • REN antibody
    • Retinoic acid EGF NGF induced gene protein antibody
    see all

Anti-KCTD11 antibody images

  • Lane 1 : Anti-KCTD11 antibody (ab113423) at 1 µg/ml
    Lane 2 : Anti-KCTD11 antibody (ab113423) at 1 mg/ml
    Lane 3 : anti-DYKDDDDK Tag at 1/5000 dilution

    Lane 1 : HEK293 lysate, (in RIPA buffer) overexpressing Human KCTD11 with DYKDDDDK tag at 10 µg
    Lane 2 : HEK293 lysate, Mock-transfected
    Lane 3 : HEK293 lysate, (in RIPA buffer) overexpressing Human KCTD11 with DYKDDDDK tag at 10 µg

    Developed using the ECL technique

    Predicted band size : 26 kDa

References for Anti-KCTD11 antibody (ab113423)

ab113423 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"