Overview

  • Product nameAnti-KCTD11 antibody
    See all KCTD11 primary antibodies
  • Description
    Rabbit polyclonal to KCTD11
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    A region within synthetic peptide: ILNFLRLGRL DLPRGYGETA LLRAEADFYQ IRPLLDALRE LEASQGTPAP, corresponding to N terminal amino acids 36-85 of Human KCTD11

  • Positive control
    • HepG2 cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab33059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 26 kDa (predicted molecular weight: 26 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA 1/62500.

Target

  • RelevanceThe KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling. Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state.
  • Database links
  • Alternative names
    • C 17 orf 36 antibody
    • C17orf36 antibody
    • MGC 129844 antibody
    • Potassium channel tetramerisation domain containing 11 antibody
    • REN antibody
    • Retinoic acid EGF NGF induced gene protein antibody
    see all

Anti-KCTD11 antibody images

  • Anti-KCTD11 antibody (ab33059) at 1.25 µg/ml + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti Rabbit IgG at 1/50000 dilution

    Predicted band size : 26 kDa
    Observed band size : 26 kDa

References for Anti-KCTD11 antibody (ab33059)

ab33059 has not yet been referenced specifically in any publications.

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