Anti-KDEL Receptor antibody [KR-10] (ab69659)
Key features and details
- Mouse monoclonal [KR-10] to KDEL Receptor
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG1
Related conjugates and formulations
Overview
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Product name
Anti-KDEL Receptor antibody [KR-10]
See all KDEL Receptor primary antibodies -
Description
Mouse monoclonal [KR-10] to KDEL Receptor -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat -
Immunogen
Synthetic peptide corresponding to Cow KDEL Receptor aa 192-212 conjugated to keyhole limpet haemocyanin. 21 residue synthetic peptide.
Sequence:CDFFYLYITKVLKGKKLSLPA
Database link: Q99JH8 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
KR-10 -
Isotype
IgG1 -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Conjugation kits
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Corresponding Antibody
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab69659 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (2) |
1/1000. Predicted molecular weight: 24 kDa.
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Notes |
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WB
1/1000. Predicted molecular weight: 24 kDa. |
Target
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Function
Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. -
Sequence similarities
Belongs to the ERD2 family. -
Post-translational
modificationsPhosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function. -
Cellular localization
Cytoplasmic vesicle, COPI-coated vesicle membrane. Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. - Information by UniProt
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Database links
- Entrez Gene: 361577 Rat
- SwissProt: Q569A6 Rat
- Unigene: 1819 Rat
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Alternative names
- ER lumen protein retaining receptor 1 antibody
- ER lumen protein-retaining receptor 1 antibody
- ERD 2 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (11)
ab69659 has been referenced in 11 publications.
- Chiu M et al. Diverse cellular morphologies during lumen maturation in Anopheles gambiae larval salivary glands. Insect Mol Biol 30:210-230 (2021). PubMed: 33305876
- Dai Z et al. Drosophila Caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes. PLoS Genet 16:e1009140 (2020). PubMed: 33057338
- Bikard Y et al. The KDEL receptor has a role in the biogenesis and trafficking of the epithelial sodium channel (ENaC). J Biol Chem 294:18324-18336 (2019). PubMed: 31653700
- Bartels AK et al. KDEL Receptor 1 Contributes to Cell Surface Association of Protein Disulfide Isomerases. Cell Physiol Biochem 52:850-868 (2019). PubMed: 30958660
- Lo Piccolo L et al. FUS toxicity is rescued by the modulation of lncRNA hsr? expression in Drosophila melanogaster. Sci Rep 7:15660 (2017). PubMed: 29142303