Anti-KDM1 / LSD1 antibody - ChIP Grade (ab17721)

Publishing research using ab17721? Please let us know so that we can cite the reference in this datasheet.

ab17721 has been referenced in 53 publications.

  • Petell CJ  et al. An epigenetic switch regulates de novo DNA methylation at a subset of pluripotency gene enhancers during embryonic stem cell differentiation. Nucleic Acids Res 44:7605-17 (2016). WB, IP ; Mouse . PubMed: 27179026
  • Joo YA  et al. Skin Barrier Recovery by Protease-Activated Receptor-2 Antagonist Lobaric Acid. Biomol Ther (Seoul) 24:529-35 (2016). PubMed: 27169822
  • Zeng X  et al. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev 30:1822-36 (2016). PubMed: 27566776
  • Sáez JE  et al. Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation. PLoS One 10:e0131760 (2015). PubMed: 26111147
  • Joiner AM  et al. Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium. J Neurosci 35:13761-72 (2015). IHC ; Mouse . PubMed: 26446227
  • Ferrari-Amorotti G  et al. Suppression of invasion and metastasis of triple-negative breast cancer lines by pharmacological or genetic inhibition of slug activity. Neoplasia 16:1047-58 (2014). PubMed: 25499218
  • Su CH  et al. An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells. Nucleic Acids Res 42:3073-88 (2014). ChIP ; Human . PubMed: 24371278
  • Yin F  et al. LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16. Mol Cell Biol 34:158-79 (2014). PubMed: 24190971
  • Seki M  et al. A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells. PLoS One 9:e95374 (2014). CHIPseq ; Mouse . PubMed: 24752154
  • Upadhyay G  et al. Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation. Proc Natl Acad Sci U S A 111:8071-6 (2014). PubMed: 24843136
  • Yokoyama A  et al. Identification of Myelin Transcription Factor 1 (MyT1) as a Subunit of the Neural Cell Type-specific Lysine-specific Demethylase 1 (LSD1) Complex. J Biol Chem 289:18152-18162 (2014). WB, ChIP . PubMed: 24828497
  • Ray SK  et al. CtBP and Associated LSD1 Are Required for Transcriptional Activation by NeuroD1 in Gastrointestinal Endocrine Cells. Mol Cell Biol 34:2308-2317 (2014). PubMed: 24732800
  • Liu D & Zempleni J Transcriptional regulation of the albumin gene depends on the removal of histone methylation marks by the FAD-dependent monoamine oxidase lysine-specific demethylase 1 in HepG2 human hepatocarcinoma cells. J Nutr 144:997-1001 (2014). Human . PubMed: 24744315
  • Derr RS  et al. High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients. BMC Cancer 14:604 (2014). IHC-P ; Human . PubMed: 25139823
  • Liu D & Zempleni J Low activity of LSD1 elicits a pro-inflammatory gene expression profile in riboflavin-deficient human T Lymphoma Jurkat cells. Genes Nutr 9:422 (2014). WB ; Human . PubMed: 25103574
  • Ketscher A  et al. LSD1 controls metastasis of androgen-independent prostate cancer cells through PXN and LPAR6. Oncogenesis 3:e120 (2014). CHIPseq ; Human . PubMed: 25285406
  • Lin S  et al. Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. J Biol Chem 288:6238-47 (2013). PubMed: 23349461
  • Kerenyi MA  et al. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife 2:e00633 (2013). CHIPseq ; Mouse . PubMed: 23795291
  • Yakulov T  et al. Wnt3a-dependent and -independent protein interaction networks of chromatin-bound ß-catenin in mouse embryonic stem cells. Mol Cell Proteomics 12:1980-94 (2013). PubMed: 23592333
  • Pan D  et al. Suppression of gluconeogenic gene expression by LSD1-mediated histone demethylation. PLoS One 8:e66294 (2013). WB ; Mouse, Human . PubMed: 23755305
  • Maksakova IA  et al. Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells. Epigenetics Chromatin 6:15 (2013). WB . PubMed: 23735015
  • Li L  et al. Targeted disruption of hotair leads to homeotic transformation and gene derepression. Cell Rep 5:3-12 (2013). ChIP ; Mouse . PubMed: 24075995
  • Layman WS  et al. Epigenetic alterations by NuRD and PRC2 in the neonatal mouse cochlea. Hear Res 304:167-78 (2013). IHC-Fr ; Mouse . PubMed: 23911933
  • Zhang X  et al. Pluripotent stem cell protein Sox2 confers sensitivity to LSD1 inhibition in cancer cells. Cell Rep 5:445-57 (2013). ChIP ; Human . PubMed: 24139802
  • Bao J  et al. Expression profiling reveals developmentally regulated lncRNA repertoire in the mouse male germline. Biol Reprod 89:107 (2013). IP ; Mouse . PubMed: 24048575
  • Konovalov S & Garcia-Bassets I Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines. J Ovarian Res 6:75 (2013). WB . PubMed: 24165091
  • Whyte WA  et al. Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature 482:221-5 (2012). PubMed: 22297846
  • Hisada K  et al. RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells. Mol Cell Biol 32:1139-49 (2012). WB ; Mouse . PubMed: 22269950
  • Le Douce V  et al. LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing. Nucleic Acids Res 40:1904-15 (2012). WB, ICC/IF, ChIP . PubMed: 22067449
  • Macfarlan TS  et al. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev 25:594-607 (2011). PubMed: 21357675
  • Cui S  et al. Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic {beta}-Type Globin Promoters in Differentiated Adult Erythroid Cells. Mol Cell Biol 31:3298-311 (2011). WB, ChIP ; Mouse . PubMed: 21670149
  • Wu CY  et al. Cryptotanshinone down-regulates androgen receptor signaling by modulating lysine-specific demethylase 1 function. Int J Cancer : (2011). PubMed: 22052438
  • Wang Q  et al. Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res 21:1424-35 (2011). WB ; Mouse . PubMed: 21727907
  • Lee SW  et al. ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1. J Biol Chem 285:18-29 (2010). WB ; Human . PubMed: 19880879
  • Anguita E  et al. GFI1B controls its own expression binding to multiple sites. Haematologica 95:36-46 (2010). PubMed: 19773260
  • van den Berg DL  et al. An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 6:369-81 (2010). PubMed: 20362541
  • Lin Y  et al. The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J : (2010). IHC-P ; Human . PubMed: 20389281
  • Rai K  et al. DNA Demethylase Activity Maintains Intestinal Cells in an Undifferentiated State Following Loss of APC. Cell 142:930-42 (2010). ChIP ; Human . PubMed: 20850014
  • Choi J  et al. Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem Biophys Res Commun 401:327-32 (2010). WB, ICC/IF, IHC-P, ChIP, IP ; Mouse . PubMed: 20833138
  • Laurent B  et al. Gfi-1B promoter remains associated with active chromatin marks throughout erythroid differentiation of human primary progenitor cells. Stem Cells 27:2153-62 (2009). WB, ChIP ; Human . PubMed: 19522008
  • Saramäki A  et al. Cyclical Chromatin Looping and Transcription Factor Association on the Regulatory Regions of the p21 (CDKN1A) Gene in Response to 1{alpha},25-Dihydroxyvitamin D3. J Biol Chem 284:8073-82 (2009). ChIP ; Human . PubMed: 19122196
  • Zhu J  et al. Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. J Exp Med 206:329-41 (2009). ChIP ; Mouse . PubMed: 19188499
  • Gu H & Roizman B Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1. J Virol 83:4376-85 (2009). WB, ICC/IF, IP ; Human . PubMed: 19193804
  • Aslan JE  et al. Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Mol Cell 34:497-509 (2009). ChIP ; Human . PubMed: 19481529
  • Turunen MP  et al. Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. Circ Res 105:604-9 (2009). ChIP . PubMed: 19696410
  • McColl G  et al. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem 283:350-7 (2008). WB ; Human . PubMed: 17959600
  • Seneda MM  et al. Developmental regulation of histone H3 methylation at lysine 4 in the porcine ovary. Reproduction 135:829-38 (2008). IHC-P ; Pig . PubMed: 18502896
  • Tsai WW  et al. p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol 28:5139-46 (2008). ChIP, IP ; Human, Mouse . PubMed: 18573881
  • Godmann M  et al. Dynamic regulation of histone H3 methylation at lysine 4 in mammalian spermatogenesis. Biol Reprod 77:754-64 (2007). IHC-P ; Mouse . PubMed: 17634443
  • Scoumanne A & Chen X The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners. J Biol Chem 282:15471-5 (2007). PubMed: 17409384
  • Szewczuk LM  et al. Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry 46:6892-902 (2007). PubMed: 17511474
  • Sánchez C  et al. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol Cell Proteomics 6:820-34 (2007). PubMed: 17296600
  • Forneris F  et al. A highly specific mechanism of histone H3-K4 recognition by histone demethylase LSD1. J Biol Chem 281:35289-95 (2006). PubMed: 16987819

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