Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.
Belongs to the JHDM2 histone demethylase family. Contains 1 JmjC domain.
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.