Anti-KDM4B / JMJD2B antibody (ab80473)

Overview

  • Product nameAnti-KDM4B / JMJD2B antibody
    See all KDM4B / JMJD2B primary antibodies
  • Description
    Rabbit polyclonal to KDM4B / JMJD2B
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla
  • Immunogen

    Synthetic peptide corresponding to a region between residue 625 and 675 of Human KDM4B/ JMJD2B (NP_055830.1)

  • Positive control
    • Whole cell lysate from HeLa cells.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab80473 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionHistone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
    • Sequence similaritiesBelongs to the JHDM3 histone demethylase family.
      Contains 1 JmjC domain.
      Contains 1 JmjN domain.
      Contains 2 PHD-type zinc fingers.
      Contains 2 Tudor domains.
    • DomainThe 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • JHDM3B antibody
      • JmjC domain-containing histone demethylation protein 3B antibody
      • JMJD2B antibody
      • Jumonji domain containing protein 2B antibody
      • Jumonji domain-containing protein 2B antibody
      • Kdm4b antibody
      • KDM4B_HUMAN antibody
      • KIAA0876 antibody
      • Lysine-specific demethylase 4B antibody
      see all

    References for Anti-KDM4B / JMJD2B antibody (ab80473)

    ab80473 has not yet been referenced specifically in any publications.

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    In regards to the homology observed between the sequence provided and the immunogen used to raise the antibodies mentioned, the highest percentage corresponds to ab91549, which shares 75% of the sequence.
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