This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Anti-KDM4C / GASC1 / JMJD2C antibody (ab40173)

Overview

Properties

Applications

  • Application notesThis antibody gave a positive result in ELISA against the immunizing peptide (ab41577).
    Not yet tested in other applications.

    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionHistone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
    • Tissue specificityOverexpressed in several esophageal squamous cell carcinomas (ESCs).
    • Sequence similaritiesBelongs to the JHDM3 histone demethylase family.
      Contains 1 JmjC domain.
      Contains 1 JmjN domain.
      Contains 2 PHD-type zinc fingers.
      Contains 2 Tudor domains.
    • DomainThe 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Alternative names
      • bA146B14.1 antibody
      • GASC 1 protein antibody
      • GASC-1 protein antibody
      • GASC1 antibody
      • Gene amplified in squamous cell carcinoma 1 protein antibody
      • JHDM3C antibody
      • JmjC domain containing histone demethylation protein 3C antibody
      • JmjC domain-containing histone demethylation protein 3C antibody
      • JMJD2C antibody
      • Jumonji domain containing 2C antibody
      • Jumonji domain containing protein 2C antibody
      • Jumonji domain-containing protein 2C antibody
      • Kdm4c antibody
      • KDM4C_HUMAN antibody
      • Lysine (K) specific demethylase 4C antibody
      • Lysine-specific demethylase 4C antibody
      • TDRD14C antibody
      • Tudor domain containing 14C antibody
      see all

    References for Anti-KDM4C / GASC1 / JMJD2C antibody (ab40173)

    ab40173 has not yet been referenced specifically in any publications.

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