Anti-KDM5A / Jarid1A / RBBP2 antibody (ab92533)

Overview

  • Product nameAnti-KDM5A / Jarid1A / RBBP2 antibody
    See all KDM5A / Jarid1A / RBBP2 primary antibodies
  • Description
    Rabbit polyclonal to KDM5A / Jarid1A / RBBP2
  • Tested applicationsSuitable for: IHC-P, ICCmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Dog, Gorilla, Chinese Hamster, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human KDM5A/ Jarid1A/ RBBP2 aa 1640-1690.

  • Positive control
    • Human prostate carcinoma.
  • General notes

    Concentration is optimized for IHC and not determined

Properties

Applications

Our Abpromise guarantee covers the use of ab92533 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.
ICC 1/50 - 1/500.

Target

  • FunctionHistone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12.
  • Sequence similaritiesBelongs to the JARID1 histone demethylase family.
    Contains 1 ARID domain.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
    Contains 3 PHD-type zinc fingers.
  • DomainThe GSGFP motif is required for the interaction with SUZ12.
  • Cellular localizationNucleus > nucleolus. Occupies promoters of genes involved in RNA metabolism and mitochondrial function.
  • Information by UniProt
  • Database links
  • Alternative names
    • Histone demethylase JARID1A antibody
    • JARID1A antibody
    • Jumonji/ARID domain containing protein 1A antibody
    • Jumonji/ARID domain-containing protein 1A antibody
    • Kdm5a antibody
    • KDM5A_HUMAN antibody
    • Lysine-specific demethylase 5A antibody
    • RBBP-2 antibody
    • RBBP2 antibody
    • RBP2 antibody
    • Retinoblastoma binding protein 2 antibody
    • Retinoblastoma-binding protein 2 antibody
    see all

Anti-KDM5A / Jarid1A / RBBP2 antibody images

  • ab92533 at 1/250 dilution staining KDM5A / Jarid1A / RBBP2 in human prostate carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
  • Immunohistochemical analysis of parafin embedded human breast carcinoma tissue labelling KDM5A/Jarid1A/RBBP2 with ab92533 at 1 in 250 dilution.

References for Anti-KDM5A / Jarid1A / RBBP2 antibody (ab92533)

ab92533 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"