Anti-KDM5B / PLU1 / Jarid1B antibody (ab84883)

Overview

  • Product name
    Anti-KDM5B / PLU1 / Jarid1B antibody
    See all KDM5B / PLU1 / Jarid1B primary antibodies
  • Description
    Rabbit polyclonal to KDM5B / PLU1 / Jarid1B
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • Immunogen

    Synthetic peptide corresponding to a region between residue 1494 and 1544 of human KDM5B/ PLU1/ Jarid1B (accession number: NP_006609.3)

  • Positive control
    • Human Controls: Breast Carcinoma, Prostate Carcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab84883 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
    • Tissue specificity
      Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).
    • Sequence similarities
      Belongs to the JARID1 histone demethylase family.
      Contains 1 ARID domain.
      Contains 1 JmjC domain.
      Contains 1 JmjN domain.
      Contains 3 PHD-type zinc fingers.
    • Domain
      Both the JmjC domain and the JmjN domain are required for enzymatic activity.
      The 2 first PHD-type zinc finger domains are required for transcription repression activity.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cancer/testis antigen 31 antibody
      • CT31 antibody
      • Histone demethylase JARID1B antibody
      • JARID1B antibody
      • Jumonji AT rich interactive domain 1B antibody
      • Jumonji/ARID domain-containing protein 1B antibody
      • Kdm5b antibody
      • KDM5B_HUMAN antibody
      • Lysine (K) specific demethylase 5B antibody
      • Lysine demethylase 5B antibody
      • Lysine specific demethylase 5B antibody
      • Lysine-specific demethylase 5B antibody
      • PLU-1 antibody
      • PLU1 antibody
      • PPP1R98 antibody
      • Protein phosphatase 1 regulatory subunit 98 antibody
      • PUT1 antibody
      • putative DNA/chromatin binding motif antibody
      • RBBP2H1A antibody
      • RBP2 like antibody
      • RBP2-H1 antibody
      • Retinoblastoma-binding protein 2 homolog 1 antibody
      • Retinoblastoma-binding protein 2 homolog 1A antibody
      see all

    Images

    • Detection of Human Jarid1B in a formalin-fixed paraffin-embedded section of human prostate carcinoma by Immunohistochemistry using ab84883 at a dilution of 1:500. Detection: DAB staining.
    • Detection of Human Jarid1B in a formalin-fixed paraffin-embedded section of human breast carcinoma by Immunohistochemistry using ab84883 at a dilution of 1:250. Detection: DAB staining.

    References

    ab84883 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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