Overview

  • Product name
  • Description
    Rabbit polyclonal to Keratin 12
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide from a region between amino acids 449-479 from the C-terminal region of Human Keratin 12 (NP_000214.1).

  • Positive control
    • K562 cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab113039 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 54 kDa.

Target

  • Function
    May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity.
  • Tissue specificity
    Cornea specific.
  • Involvement in disease
    Defects in KRT12 are a cause of Meesmann corneal dystrophy (MECD) [MIM:122100]; also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
  • Sequence similarities
    Belongs to the intermediate filament family.
  • Information by UniProt
  • Database links
  • Alternative names
    • CK-12 antibody
    • Cytokeratin-12 antibody
    • K12 antibody
    • K1C12_HUMAN antibody
    • Keratin 12 antibody
    • Keratin antibody
    • Keratin, type I cytoskeletal 12 antibody
    • Keratin-12 antibody
    • KRT12 antibody
    • type I cytoskeletal 12 antibody
    see all

Images

  • Anti-Keratin 12 antibody (ab113039) at 1/100 dilution + K562 cell line lysate at 35 µg

    Predicted band size : 54 kDa

References

ab113039 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab113039.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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