Anti-Keratin 12 antibody [EPR1609(2)] (ab124975)


  • Product nameAnti-Keratin 12 antibody [EPR1609(2)]
    See all Keratin 12 primary antibodies
  • Description
    Rabbit monoclonal [EPR1609(2)] to Keratin 12
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to residues near the C-terminus of Human Keratin 12 protein (Q99456).

  • Positive control
    • Rat eyeball lysate.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab124975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 54 kDa.
  • Application notesIs unsuitable for IP.
  • Target

    • FunctionMay play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity.
    • Tissue specificityCornea specific.
    • Involvement in diseaseDefects in KRT12 are a cause of Meesmann corneal dystrophy (MECD) [MIM:122100]; also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
    • Sequence similaritiesBelongs to the intermediate filament family.
    • Information by UniProt
    • Database links
    • Alternative names
      • CK-12 antibody
      • Cytokeratin-12 antibody
      • K12 antibody
      • K1C12_HUMAN antibody
      • Keratin 12 antibody
      • Keratin antibody
      • Keratin, type I cytoskeletal 12 antibody
      • Keratin-12 antibody
      • KRT12 antibody
      • type I cytoskeletal 12 antibody
      see all

    Anti-Keratin 12 antibody [EPR1609(2)] images

    • Anti-Keratin 12 antibody [EPR1609(2)] (ab124975) at 1/1000 dilution + Rat eyeball lysate at 10 µg

      Predicted band size : 54 kDa

    References for Anti-Keratin 12 antibody [EPR1609(2)] (ab124975)

    This product has been referenced in:

    See 1 Publication for this product

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