Overview

  • Product nameKetoconazole
  • Description
    Potent cytochrome P450 inhibitor. Antifungal agent.
  • Biological descriptionPotent cytochrome P450 inhibitor (Ki values are 26.7 and 109 nM at CYP3A4 and CYP3A5, respectively). Antifungal agent. Additionally, shows activity at human androgen receptors.
  • Purity> 99%

Properties

    References for Ketoconazole (ab120620)

    This product has been referenced in:
    • Shah SS  et al. Inhibitory effects of ketoconazole, cimetidine and erythromycin on hepatic CYP3A activities in cats. J Vet Med Sci 71:1151-9 (2009). Read more (PubMed: 19801894) »
    • Gibbs MA  et al. Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. Drug Metab Dispos 27:180-7 (1999). Read more (PubMed: 9929500) »
    • Eil C Ketoconazole binds to the human androgen receptor. Horm Metab Res 24:367-70 (1992). Read more (PubMed: 1526623) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"