Overview

  • Product name
  • Description
    Mouse polyclonal to KHDRBS3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Full length human KHDRBS3 protein (NP_006549).

  • Positive control
    • Rat brain tissue lysate. KHDRBS3 transfected 293T lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab68515 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa).

Target

  • Function
    RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression.
  • Tissue specificity
    Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.
  • Sequence similarities
    Belongs to the KHDRBS family.
    Contains 1 KH domain.
  • Domain
    The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated.
  • Cellular localization
    Nucleus. Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
  • Information by UniProt
  • Database links
  • Alternative names
    • Etle antibody
    • etoile antibody
    • KH domain containing RNA binding signal transduction associated 3 antibody
    • KH domain containing RNA binding signal transduction associated protein 3 antibody
    • KH domain-containing antibody
    • KHDR3_HUMAN antibody
    • Khdrbs3 antibody
    • RNA binding protein T Star antibody
    • RNA-binding antibody
    • RNA-binding protein T-Star antibody
    • SALP antibody
    • Sam68 like mammalian protein 2 antibody
    • Sam68 like phosphotyrosine protein antibody
    • Sam68 like phosphotyrosine protein T STAR antibody
    • Sam68-like mammalian protein 2 antibody
    • Sam68-like phosphotyrosine protein antibody
    • signal transduction-associated protein 3 antibody
    • SLM 2 antibody
    • SLM-2 antibody
    • SLM2 antibody
    • T STAR antibody
    • TSTAR antibody
    see all

Images

  • Anti-KHDRBS3 antibody (ab68515) at 1/500 dilution + rat brain tissue lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 39 kDa
    Observed band size : 39 kDa
  • All lanes : Anti-KHDRBS3 antibody (ab68515) at 1/500 dilution

    Lane 1 : KHDRBS3 transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 39 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)

References

ab68515 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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