Overview

  • Product nameAnti-KIAA1967 antibody
    See all KIAA1967 primary antibodies
  • Description
    Rabbit polyclonal to KIAA1967
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • Immunogen

    Synthetic peptide corresponding to a region between residues 1 and 50 of Human KIAA1967 (UniProt: Q8N163).

  • Positive control
    • Human: breast carcinoma, colon carcinoma, metastatic lymph node, ovarian carcinoma, pancreatic islet cell tumor, skin basal cell carcinoma, stomach adenocarcinoma, testicular seminoma. Mouse: squamous cell carcinoma.
  • General notes

    Concentration is optimized for IHC and not determined

Properties

Applications

Our Abpromise guarantee covers the use of ab84384 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500. Epitope exposure with citrate buffer will enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCore component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity.
    • Tissue specificityExpressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • CCAR2 antibody
      • Cell cycle and apoptosis regulator 2 antibody
      • Cell division cycle and apoptosis regulator protein 2 antibody
      • DBC-1 antibody
      • DBC.1 antibody
      • DBC1 antibody
      • DBIRD complex subunit KIAA1967 antibody
      • Deleted in breast cancer 1 antibody
      • Deleted in breast cancer gene 1 protein antibody
      • K1967_HUMAN antibody
      • KIAA1967 antibody
      • NET35 antibody
      • p30 DBC antibody
      • p30 DBC protein antibody
      • p30DBC antibody
      see all

    Anti-KIAA1967 antibody images

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast tumor tissue using 1/250 ab84384, followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma tissue using 1/250 ab84384, followed by DAB staining.

    References for Anti-KIAA1967 antibody (ab84384)

    This product has been referenced in:
    • Cha EJ  et al. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res 15:4453-9 (2009). Read more (PubMed: 19509139) »

    See 1 Publication for this product

    Product Wall

    Vielen Dank für Ihre Anfrage.
    Leider gibt der Hersteller dieses Antikörpers keine genauen Konzentrationsangaben weiter.
    Ich möchte Sie deshalb bitten eine Konzentration von ca. 1mg/ml anzunehmen, falls Sie eine Isotypen-Kontrolle verwenden. <...

    Read More

    Vielen Dank für Ihre Anfrage. Ich kann Ihnen nun bestätigen, dass ab84384 (Anti-DBC1 antibody) eine Konzentration von ca. 1mg/ml hat. Außerdem kann ich Ihnen bestätigen, dass das Lot, das im Moment von ab114033 (Anti-CD26 antibody [11D7]) vorrätig i...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"