Overview

  • Product name
  • Description
    Rabbit polyclonal to Kidins220
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 1517-1547 of Human Kidins220 (Accessions: Q9ULH0, NP_065789.1)

  • Positive control
    • K562 cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab124194 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 197 kDa.

Target

  • Function
    Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
  • Tissue specificity
    Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
  • Sequence similarities
    Contains 12 ANK repeats.
    Contains 1 KAP NTPase domain.
  • Domain
    The transmembrane domain mediates interaction with NTRK1.
  • Post-translational
    modifications
    Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF).
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ankyrin repeat-rich membrane-spanning protein antibody
    • arms antibody
    • KDIS_HUMAN antibody
    • kidins220 antibody
    • Kinase D interacting substance of 220 kDa antibody
    • Kinase D-interacting substrate of 220 kDa antibody
    • rgd 619949 antibody
    see all

Images

  • Anti-Kidins220 antibody (ab124194) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 197 kDa

References

ab124194 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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