Overview

  • Product nameAnti-Kidins220 (phospho S919) antibody
    See all Kidins220 primary antibodies
  • Description
    Rabbit polyclonal to Kidins220 (phospho S919)
  • SpecificityThis antibody recognizes a phosphoserine at position 919.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Pufferfish (Fugu), Non Human Primates, Zebrafish
  • Immunogen

    Synthetic peptide: RQMQRTITRQMpSFDLTK, corresponding to amino acids 907-923 of Human Kidins220

Properties

Applications

Our Abpromise guarantee covers the use of ab34792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 220 kDa.

Target

  • FunctionPromotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
  • Tissue specificityAbundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
  • Sequence similaritiesContains 12 ANK repeats.
    Contains 1 KAP NTPase domain.
  • DomainThe transmembrane domain mediates interaction with NTRK1.
  • Post-translational
    modifications
    Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF).
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ankyrin repeat-rich membrane-spanning protein antibody
    • arms antibody
    • KDIS_HUMAN antibody
    • kidins220 antibody
    • Kinase D interacting substance of 220 kDa antibody
    • Kinase D-interacting substrate of 220 kDa antibody
    • rgd 619949 antibody
    see all

References for Anti-Kidins220 (phospho S919) antibody (ab34792)

This product has been referenced in:
  • Li J  et al. PKD1, PKD2, and Their Substrate Kidins220 Regulate Neurotensin Secretion in the BON Human Endocrine Cell Line. J Biol Chem 283:2614-21 (2008). WB ; Human . Read more (PubMed: 18048355) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab34792.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"