• Product nameAnti-KIN antibody
    See all KIN primary antibodies
  • Description
    Rabbit polyclonal to KIN
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    A region within synthetic peptide: LEGKEQEVPT FTELSRENDE EKVTFNLSKG ACSSSGATSS KSSTLGPSAL, corresponding to internal sequence amino acids 181-230 of Human KIN


Associated products


Our Abpromise guarantee covers the use of ab56222 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1/312500.

WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 45 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionInvolved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.
  • Tissue specificityUbiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level).
  • Sequence similaritiesBelongs to the KIN17 family.
    Contains 1 C2H2-type zinc finger.
  • DomainThe C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to SH3-like domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each other by a short linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each other. A highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302 and 391 and other positively charged residues, may possibly be the site of RNA-binding.
  • Cellular localizationNucleus. Cytoplasm. During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids.
  • Information by UniProt
  • Database links
  • Alternative names
    • antigenic determinant of recA protein homolog antibody
    • Binding to curved DNA antibody
    • BTCD antibody
    • DNA/RNA-binding protein KIN17 antibody
    • HsKin17 protein antibody
    • KIN antibody
    • KIN antigenic determinant of recA protein homolog mouse antibody
    • Kin17 protein antibody
    • KIN17_HUMAN antibody
    see all

Anti-KIN antibody images

  • All lanes : Anti-KIN antibody (ab56222) at 2.5 µg/ml

    Lane 1 : Marker
    Lane 2 : Jurkat cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 45 kDa
    Observed band size : 45 kDa

References for Anti-KIN antibody (ab56222)

ab56222 has not yet been referenced specifically in any publications.

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