Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SequenceCGYEAEDQAKLFPLHQETAAS
    • Amino acids1007 to 1027

Associated products

Specifications

Our Abpromise guarantee covers the use of ab41781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    competitive binding assays

    Neutralising

    Blocking - Blocking peptide for Anti-Kinesin 5A antibody (ab5628)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • D12S1889
    • KIF 5A
    • Kif5a
    • KIF5A_HUMAN
    • Kinesin family member 5A
    • Kinesin heavy chain isoform 5A
    • Kinesin Heavy Chain Neuron Specific
    • Kinesin heavy chain neuron-specific 1
    • MY050
    • Neuronal kinesin heavy chain
    • NKHC
    • NKHC 1
    • SPG 10
    see all
  • FunctionMicrotubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).
  • Tissue specificityDistributed throughout the CNS but is highly enriched in subsets of neurons.
  • Involvement in diseaseDefects in KIF5A are the cause of spastic paraplegia autosomal dominant type 10 (SPG10) [MIM:604187]. An inherited degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
  • Sequence similaritiesBelongs to the kinesin-like protein family. Kinesin subfamily.
    Contains 1 kinesin-motor domain.
  • DomainComposed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
  • Cellular localizationCytoplasm > perinuclear region. Cytoplasm > cytoskeleton. Concentrated in the cell body of the neurons, particularly in the perinuclear region.
  • Information by UniProt

References for Kinesin 5A peptide (ab41781)

ab41781 has not yet been referenced specifically in any publications.

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