Overview

  • Product name
  • Description
    Rabbit polyclonal to KIR2DL4
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-254 of Human KIR2DL4 (UniProt Q99706).

  • Positive control
    • THP-1 whole cell lysate; HeLa cells; Human breast carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab154386 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 41 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).
ICC/IF 1/100 - 1/1000.

Target

  • Function
    Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD_antigen=CD158d antibody
    • CD158 antigen like family member D antibody
    • CD158 antigen-like family member D antibody
    • CD158d antibody
    • G9P antibody
    • KI2L4_HUMAN antibody
    • Killer cell immunoglobulin like receptor 2DL4 antibody
    • Killer cell immunoglobulin like receptor, two domains, long cytoplasmic tail, 4 antibody
    • Killer cell immunoglobulin-like receptor 2DL4 antibody
    • Killer cell inhibitory receptor 103AS antibody
    • Killer Ig receptor antibody
    • KIR 103AS antibody
    • KIR-103AS antibody
    • KIR103 antibody
    • KIR103AS antibody
    • KIR2DL4 antibody
    • MHC class I NK cell receptor KIR103AS antibody
    • Natural killer cell inhibitory receptor antibody
    • NK cell receptor antibody
    • NK cell receptor; natural killer cell inhibitory receptor antibody
    • OTTHUMP00000068612 antibody
    • OTTHUMP00000068614 antibody
    • OTTHUMP00000068615 antibody
    see all

Images

  • Anti-KIR2DL4 antibody (ab154386) at 1/1000 dilution + THP-1 whole cell lysate at 30 µg

    Predicted band size: 41 kDa



    10% SDS PAGE
  • Immunofluorescent analysis of 4% paraformaldehyde-fixed HeLa cells labeling KIR2DL4 with ab154386 at 1/500 dilution (Green). Blue: Hoechst 33342 staining.
  • Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labeling KIR2DL4 with ab154386 at 1/250 dilution.

References

This product has been referenced in:
  • Takei Y  et al. Killer cell immunoglobulin-like receptor 2DL4 is expressed in and suppresses the cell growth of Langerhans cell histiocytosis. Oncotarget 8:36964-36972 (2017). Read more (PubMed: 28445138) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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