Overview

  • Product name
  • Description
    Rabbit polyclonal to Kir4.1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Horse, Cow, Human, Macaque monkey, Gorilla, Chinese hamster
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 300 to the C-terminus of Human Kir4.1.

  • Positive control
    • This antibody gave a positive signal in Mouse Spinal cord tissue lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituent: PBS
    Note: Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab101064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).

Target

  • Function
    May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
  • Tissue specificity
    Expressed in kidney (at protein level).
  • Involvement in disease
    Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance
  • Sequence similarities
    Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
  • Cellular localization
    Membrane. Basolateral cell membrane. In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.
  • Information by UniProt
  • Database links
  • Alternative names
    • inwardly rectifying subfamily J member 10 antibody
    • ATP dependent inwardly rectifying potassium channel Kir4.1 antibody
    • ATP sensitive inward rectifier potassium channel 10 antibody
    • ATP-dependent inwardly rectifying potassium channel Kir4.1 antibody
    • ATP-sensitive inward rectifier potassium channel 10 antibody
    • BIRK10 antibody
    • Glial ATP dependent inwardly rectifying potassium channel KIR4.1 antibody
    • Inward rectifier K(+) channel Kir1.2 antibody
    • Inward rectifier K+ channel KIR1.2 antibody
    • Inwardly rectifying potassium channel Kir1.2 antibody
    • KCJ10_HUMAN antibody
    • KCNJ 10 antibody
    • Kcnj10 antibody
    • KCNJ13 PEN antibody
    • KIR1.2 antibody
    • KIR4.1 antibody
    • Potassium channel antibody
    • Potassium channel inwardly rectifying subfamily J member 10 antibody
    • Potassium inwardly rectifying channel subfamily J member 10 antibody
    • SESAME antibody
    see all

Images

  • Anti-Kir4.1 antibody (ab101064) at 1 µg/ml + Spinal Cord (Mouse) Tissue Lysate at 10 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 42 kDa


    Exposure time : 8 minutes

References

ab101064 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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