The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 44 kDa (predicted molecular weight: 44 kDa).
Use at an assay dependent dilution. Antibody detection limit dilution 1:32000.
Use a concentration of 3 - 5 µg/ml.
RelevanceATP-sensitive potassium (K(ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K(ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.
Cellular localizationCell Membrane; Multi-pass membrane protein
ab77637 at 3µg/ml staining Kir6.2 in human pancreas tissue section by Immunohistochemistry (Formalin/ PFA-fixed paraffin-embedded tissue sections). The tissue sections underwent antigen retrieval by steam with citrate buffer pH 6.0. The AP staining procedure was used for staining.
References for Anti-Kir6.2 antibody (ab77637)
has not yet been referenced specifically in any publications.
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