Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Belongs to the immunoglobulin superfamily. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Phosphorylation probably regulates the interaction with NSH2. N-glycosylated.
Cell membrane. Predominantly located at podocyte slit diaphragm.