The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-KIRREL antibody (ab82804)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Kin of IRRE like
Kin of IRRE like (Drosophila)
Kin of IRRE like protein 1
Kin of IRRE-like protein 1
Kin of irregular chiasm like protein 1
Kin of irregular chiasm-like protein 1
Nephrin like protein 1
Nephrin-like protein 1
FunctionPlays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Tissue specificityAbundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Sequence similaritiesBelongs to the immunoglobulin superfamily. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Post-translational modificationsPhosphorylation probably regulates the interaction with NSH2. N-glycosylated.
Cellular localizationCell membrane. Predominantly located at podocyte slit diaphragm.