Anti-KiSS1 receptor antibody - C-terminal (ab188995)

Overview

  • Product name
    Anti-KiSS1 receptor antibody - C-terminal
    See all KiSS1 receptor primary antibodies
  • Description
    Rabbit polyclonal to KiSS1 receptor - C-terminal
  • Specificity
    BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ZC3H3 (50%).
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Monkey
  • Immunogen

    Synthetic peptide corresponding to Human KiSS1 receptor (C terminal). 20 amino acids long.
    Database link: Q969F8

  • Positive control
    • Human brain cerebellum and human tonsil tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188995 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 - 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
  • Tissue specificity
    Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism.
  • Involvement in disease
    Defects in KISS1R are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
    Defects in KISS1R are a cause of central precocious puberty (CEPREPU) [MIM:176400]. Precocious puberty is defined as the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Central precocious puberty refers to a gonadotropin-dependent type which results from premature activation of the hypothalamic-pituitary-gonadal axis.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AXOR 12 antibody
    • AXOR12 antibody
    • G protein coupled receptor 54 antibody
    • G-protein coupled receptor 54 antibody
    • G-protein coupled receptor OT7T175 antibody
    • GPCR 54 antibody
    • GPCR54 antibody
    • GPR 54 antibody
    • GPR54 antibody
    • hOT7T175 antibody
    • Hypogonadotropin 1 antibody
    • Hypogonadotropin-1 antibody
    • Hypogonadotropin1 antibody
    • KISS 1 receptor antibody
    • KISS 1R antibody
    • KiSS-1 receptor antibody
    • KiSS-1R antibody
    • KISS1 receptor antibody
    • Kiss1r antibody
    • Kisspeptins receptor antibody
    • KISSR_HUMAN antibody
    • Metastin receptor antibody
    • OT7T175 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded human tonsil tissue labeling KiSS1 receptor with ab188995 at 5 µg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded human brain cerebellum tissue labeling KiSS1 receptor with ab188995 at 5 µg/ml.

References

ab188995 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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