Overview

  • Product nameAnti-Kisspeptin antibody
    See all Kisspeptin primary antibodies
  • Description
    Rabbit polyclonal to Kisspeptin
  • Tested applicationsSuitable for: WB, ELISA, ICCmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptides derived from internal parts of Human Kisspeptin containing pY112.

Properties

Applications

Our Abpromise guarantee covers the use of ab101017 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 15 kDa.
ELISA Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.

Target

  • FunctionMetastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
  • Tissue specificityVery high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.
  • Sequence similaritiesBelongs to the KISS1 family.
  • Post-translational
    modifications
    Processed by MMP2 and MMP9.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • KISS 1 antibody
    • KiSS 1 metastasis suppressor antibody
    • Kiss1 antibody
    • KISS1_HUMAN antibody
    • Kisspeptin 1 antibody
    • Kisspeptin 10 antibody
    • Kisspeptin 13 antibody
    • Kisspeptin 14 antibody
    • Kisspeptin antibody
    • Kisspeptin-1 antibody
    • Kisspeptin-10 antibody
    • Kisspeptin-54 antibody
    • Kisspeptin1 antibody
    • Malignant melanoma metastasis suppressor antibody
    • Metastasis suppressor KiSS 1 antibody
    • Metastasis suppressor KiSS1 antibody
    • Metastin antibody
    • MGC39258 antibody
    see all

References for Anti-Kisspeptin antibody (ab101017)

ab101017 has not yet been referenced specifically in any publications.

Product Wall

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