Overview

  • Product nameAnti-Kisspeptin antibody
    See all Kisspeptin primary antibodies
  • Description
    Mouse monoclonal to Kisspeptin
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: PGEQSLPCTE RKPAATARLS RRGTSLSPPP ESSGSPQQPG LSAPHSRQIP APQGAVLVQR EKDLPNYNWN SFGLRFGKRE AAPGNHGRSA GRGWGAGAGQ , corresponding to amino acids 46-146 of Human Kisspeptin

Properties

Applications

Our Abpromise guarantee covers the use of ab55384 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMetastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
    • Tissue specificityVery high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.
    • Sequence similaritiesBelongs to the KISS1 family.
    • Post-translational
      modifications
      Processed by MMP2 and MMP9.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • KISS 1 antibody
      • KiSS 1 metastasis suppressor antibody
      • Kiss1 antibody
      • KISS1_HUMAN antibody
      • Kisspeptin 1 antibody
      • Kisspeptin 10 antibody
      • Kisspeptin 13 antibody
      • Kisspeptin 14 antibody
      • Kisspeptin antibody
      • Kisspeptin-1 antibody
      • Kisspeptin-10 antibody
      • Kisspeptin-54 antibody
      • Kisspeptin1 antibody
      • Malignant melanoma metastasis suppressor antibody
      • Metastasis suppressor KiSS 1 antibody
      • Metastasis suppressor KiSS1 antibody
      • Metastin antibody
      • MGC39258 antibody
      see all

    Anti-Kisspeptin antibody images

    • Kisspeptin antibody (ab55384) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human prostate.
    • Western blot against tagged recombinant protein immunogen using ab55384 Kisspeptin antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-Kisspeptin antibody (ab55384)

    ab55384 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab55384.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"